Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The New Munich Elbow Soft Tissue (MEST) classification is a reliable MRI-based injury severity grading system for acute simple elbow dislocations.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Whole body CT attenuation and volume charts from routine clinical scans via LLM report filtering.

NPJ digital medicine·2026
Same author

Erratum for: Associations of MRI-derived Paraspinal IMAT and LMM with Cardiometabolic Risk Factors: Results from a German Cohort.

Radiology·2026
Same author

MHub.ai: A Standardized Platform for Reproducible AI Research in Medical Imaging.

Research square·2026
Same author

GPT-4.1 and Llama 3.3 70 fail to detect clinically relevant errors in radiology reports in zero-shot evaluation.

European radiology·2026
Same author

Genestrip: exact and efficient read classification for selected groups of organisms.

BMC bioinformatics·2026

相关实验视频

Updated: Jun 11, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

983

超越形态学:在肺损伤分类中的定量MR放松计.

Markus Graf1, Alexander W Marka1, Andreas Wachter1

  • 1Department of Diagnostic and Interventional Radiology, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Cancers
|October 29, 2025
PubMed
概括

定量磁共振 (MR) 放松计准确地区分使用T1和T2映射的良性和恶性肺病变. 这种无辐射成像技术在减少肺结节诊断的侵入性手术方面表现有前途.

关键词:
通过MR放松计测量.T1绘制地图的 T1 绘制地图.T2映射 T2映射 T2映射 T2映射 T2映射 T2映射肺部的病变 肺部的病变肺结节的分类 肺结节的分类

更多相关视频

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

4.1K
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
03:38

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

Published on: June 20, 2025

833

相关实验视频

Last Updated: Jun 11, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
02:09

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

983
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

4.1K
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
03:38

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models

Published on: June 20, 2025

833

科学领域:

  • 放射学 放射学是指放射学
  • 医疗成像医学成像
  • 在瘤学瘤学.

背景情况:

  • 肺结节带来了诊断挑战,因为良性和恶性病变的成像特征重叠.
  • 目前的诊断方法如CT,PET和活检都有局限性.
  • 定量MR放松计提供了一种无辐射的方法来评估组织特征.

研究的目的:

  • 评估定量MR放松计 (T1和T2映射) 在区分良性和恶性肺病变方面的疗效.
  • 评估MR放松计在区分原发性肺癌与肺转移中的潜力.
  • 探索MR放松计作为传统诊断方法的非侵入性替代方案.

主要方法:

  • 对64名患有76个肺病变的患者进行前性研究.
  • 在3TMRI获得T1和T2放松时间图.
  • 通过两个独立的读取器对平均T1和T2值进行量化.
  • 统计分析以比较病变类型之间的放松时间,并评估分类准确性.

主要成果:

  • 在不同类型的病变中发现T1和T2值的显著差异 (p < 0.001).
  • 良性病变显示高T2和低T1值;恶性瘤显示较低的T2和较高的T1值.
  • 二元分类 (良性与恶性) 达到95.7%的准确性,具有高灵敏度和特异性.
  • 区分恶性亚型和多类分类的准确性较低.

结论:

  • 定量MR放松度 (T1/T2映射) 有效地区分良性和恶性肺病变.
  • 这种无辐射技术显示出改善肺结节诊断的潜力.
  • 核磁共振放松计可能有助于减少对侵入性诊断程序的需要.