肺癌中通过空气空间传播的多学科视角:叙述性审查
Riccardo Orlandi1,2, Lorenzo Bramati1, Maria C Andrisani3
1Department of Thoracic Surgery, University of Milan, 20122 Milan, Italy.
Cancers
|October 29, 2025
概括
肺癌中通过空气空间传播 (STAS) 表明瘤细胞侵入空气空间,导致复发和不良预后. 多学科的方法对于其检测和管理至关重要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 放射学 放射学是一门学科.
- 外科手术 医疗外科手术
- 分子生物学分子生物学
背景情况:
- 通过空气空间传播 (STAS) 是肺癌中瘤入侵的新兴模式,由世卫组织于2015年承认.
- STAS涉及瘤细胞扩散到主要瘤之外,与增加复发风险和较差的患者结果相关.
研究的目的:
- 从多学科的角度审查肺癌中的STAS,整合病理学,放射学,瘤学和手术的见解.
- 评估STAS的临床意义,诊断挑战和治疗影响.
- 评估STAS作为肺癌管理中的分期标准的潜力.
主要方法:
- 这是一篇综合病理学,放射学,瘤学和外科手术数据的叙事性综述.
- 与STAS相关的分子生物学发现也被纳入.
- 文献搜索和对肺癌中STAS现有知识的综合.
主要成果:
- 在病理上,STAS的特征是空气空间中的自由瘤细胞,与复发有关.
- 放射性标志物,如和高FDG吸收可能表明STAS,但手术前诊断是具有挑战性的.
- 瘤学数据将STAS与侵略性行为,淋巴血管入侵和特定的分子变化联系在一起 (例如,EGFR野生型,ALK/ROS1重组,高Ki-67).
- 手术切除带有复发的风险,质疑最佳手术策略.
- STAS的性质 (入侵与工件) 需要标准化的病理评估.
结论:
- STAS是肺癌预后的一个重要因素,需要改进检测方法.
- 多学科融合是有效的STAS管理和治疗决策的关键.
- 需要进一步的研究来规范STAS评估,并考虑其在肺癌分期中的作用.
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