热带儿童对BTEX的内部暴露:暴露是否加快了青春期的发展?
1Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment and Climate, Jinan University, Guangzhou 511443, China.
Antioxidants (Basel, Switzerland)
|October 29, 2025
概括
,多,乙和 (BTEX) 暴露可能会影响儿童的青春期时间. 这项研究发现BTEX代谢物与早期或早熟的青春期之间存在关联,但没有发现DNA损伤.
科学领域:
- 环境健康 环境健康
- 儿科内分泌学 儿科内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- ,,乙和 (BTEX) 是具有已知的不良健康影响的挥发性有机化合物.
- BTEX化合物具有内分泌干扰性,但它们对儿童青春期发育的影响尚不清楚.
研究的目的:
- 研究BTEX暴露与儿童早期青春期 (PP) 和早期青春期 (EP) 的发展之间的关联.
- 探索尿路BTEX代谢物,氧化DNA损伤和儿科人口中青春期时间之间的关系.
主要方法:
- 一项涉及246名被诊断患有PP或EP的儿童的病例控制研究,以及年龄和性别匹配的对照.
- 使用高性能液态染色体-并联质谱法测量尿中的BTEX代谢物和8-基-2'-脱氧氨 (8-OHdG).
- 统计分析包括二进制物流回归和分层分析,以确定关联和潜在的混因素.
主要成果:
- 与对照人群相比,患有PP和EP的儿童的尿中catechol (1,2-DB) 水平显著更高.
- 1,2-DB与EP呈阳性关联,而酸 (MU) 和酸 (PGA) 与PP和EP相对负相关.
- 氧化性DNA损伤 (8-OHdG) 与PP或EP之间没有发现显著的关系.
结论:
- 暴露于BTEX,特别是,可能会影响儿童的青春期时间.
- 该研究强调了BTEX对青春期发育的潜在内分泌干扰作用.
- 需要进一步的研究来阐明BTEX暴露的基础生物机制及其对青春期的影响.
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