心力衰竭中的氧化应激和DNA损伤生物标志物:系统性审查和元分析
Francesca Milani1,2, Annamaria Porreca1,2, Giuseppe Rosano1,3
1Department of Human Sciences and Quality of Life Promotion, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.
Antioxidants (Basel, Switzerland)
|October 29, 2025
概括
氧化应激和DNA损伤生物标志物在心力衰竭 (HF) 患者中升高. 这一元分析证实了它们与高温风暴的关联,表明它们在监测疾病进展和预测结果方面的有用性.
科学领域:
- 心脏病学 心脏病学
- 生物化学 生物化学
- 遗传学 是一个遗传学.
背景情况:
- 氧化应激是心力衰竭 (HF) 病理生理学的关键因素.
- 它有助于心肌损伤,炎症和不良的心脏重塑.
- 在HF中氧化应激和DNA损伤生物标志物的临床意义需要澄清.
研究的目的:
- 系统地审查和分析氧化应激和DNA损伤生物标志物在HF患者.
- 为了比较HF患者与健康对照者的生物标志物水平.
主要方法:
- 按照PRISMA的指导方针,对主要数据库 (PubMed,MEDLINE,Cochrane,Web of Science) 进行了系统的文献搜索.
- 随机效应模型被用于计算平均值比率 (ROM) 的95%置信区间 (CI).
- 使用I2统计和Begg的测试来评估异质性和出版偏差.
主要成果:
- 对3015名高血压患者和2704名对照组的分析显示,高血压患者的8-基-2'-脱氧氨 (8-OHdG),马隆迪化 (MDA) 和异醇含量显著增加.
- 肝炎患者的端粒长度显著缩短,这表明细胞衰老加速.
- 在包括的研究中发现了实质性的异质性.
结论:
- 这一元分析提供了强有力的证据,证明氧化应激,DNA损伤和心力衰竭之间存在关联.
- 这些生物标志物显示出监测HF进展和预测患者预后的潜力.
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