相关实验视频

Updated: Jan 13, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

双极性障碍的口腔微生物群和pri-miRNA表达:一个病例对照研究

Diego Primavera¹, Mauro Giovanni Carta^1,2,3, Massimo Tusconi⁴

¹Department of Medical Sciences and Public Health, University of Cagliari, Monserrato Blocco I (CA), 09042 Cagliari, Italy.

|October 29, 2025

概括

口腔微生物群的组成在双相情感障碍 (BD) 患者中不同,具有减少的特定细菌. 这些口腔变化可能会影响肠道健康和大脑,但炎症标志物没有显示差异.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
遗传学是一个遗传学.

背景情况:

新兴研究将肠道微生物群失调与精神症状联系起来.
人们越来越认识到口腔微生物组在情绪障碍,包括双相情绪障碍 (BD) 中的作用.
研究口腔微生物种群和与炎症相关的primiRNAs,可以深入了解口腔-肠-大脑轴.

研究的目的:

为了研究双相情感障碍 (BD) 患者的口腔微生物组成.
评估BD.中与炎症相关的primiRNAs (146a和155) 的表达.
探索口腔微生物群和primiRNAs作为BD中的生物标志物的潜力.

主要方法:

与25名BD患者和46名对照进行了匹配的病例对照研究.
用实时qPCR分析的唾液样本进行微生物分析.
通过RT-qPCR评估的pri-miRNA 146a和155表达.

主要成果:

在BD患者的口腔α-蛋白质细菌,γ-蛋白质细菌和活性细菌显著减少 (p < 0.01).
在BD队列中观察到更高的Firmicutes/Bacteroidetes比率.
在BD患者和对照人群之间,pri-miRNA 146a和155表达没有显著差异.

结论:

在BD患者中,口腔微生物群的组成发生了变化,这可能会影响全身平衡和肠-大脑轴相互作用.
146a和155的pri-miRNAs并没有作为区分BD状态的生物标志物.
这些发现是初步的,强调需要对口腔微生物组在BD病变发生过程中的作用进行更大规模的纵向研究.

关键词:

生物标志物生物标志物双相情感障碍双相情感障碍双相情感障碍所有的微生物群.在primiRNA146a中.在primiRNA 155 中,

更多相关视频

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

相关概念视频

Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...