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Updated: Jan 13, 2026

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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通过使用计算机辅助设计修改蛋白界面来预测IL-18/IL-18R结合的改善

Napat Prompat1,2, Chariya Peeyatu1, Jirakrit Saetang3

  • 1Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

Biomolecules
|October 29, 2025
PubMed
概括

使用计算方法来设计突变,以增强用于癌症免疫治疗的INTERLEUKIN-18 (IL-18) 活性. 这些设计突变显示出改善IL-18的潜力.

关键词:
细胞因子介导的免疫疗法.介质蛋白-18的使用方法分子动力学模拟模拟结构导向设计是指导设计.

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