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Updated: Jan 13, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
15:43

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

Published on: October 25, 2011

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癌症相关的纤维细胞由内皮转化为介质细胞过渡产生的:诱导因子,功能作用和转录基因证据

Junyeol Han1,2, Eung-Gook Kim3, Bo Yeon Kim1,2

  • 1Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Republic of Korea.

Biology
|October 29, 2025
PubMed
概括

内皮转移到介质细胞 (EndMT) 生成与癌症相关的纤维细胞 (CAF),这些纤维细胞驱动瘤生长和治疗耐药性. 本综述详细介绍了EndMT诱导方法及其对瘤微环境 (TME) 的影响.

关键词:
在TGF-β信号传输中.癌症相关纤维细胞 (CAF).内皮细胞到介质细胞的转变 (EndMT)单细胞RNA测序 (scRNA-seq) 是一种空间转录组学序列化 (ST-seq) 的方法瘤微环境 (TME) 是指瘤的微环境.

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