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狭窄症严重程度对阴动脉血液动力学参数的影响:流体结构相互作用研究

Nima Rahmati¹, Hamidreza Pouraliakbar², Arshia Eskandari¹

¹Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran 19991-43344, Iran.

Bioengineering (Basel, Switzerland)

|October 29, 2025

概括

常见的阴动脉狭窄症显著改变了血液流动的动态. 我们的研究显示,下游壁切应力和血栓形成风险增加,强调需要全面的血液动力学评估.

科学领域:

心血管科学心血管科学
生物医学工程生物医学工程
血液动力学血液动力学

背景情况:

常见的阴动脉狭窄会损害到下肢的血液流动.
了解血液动力学变化对于管理狭窄症至关重要.

研究的目的:

为了研究25%,50%和75%的常见阴动脉狭窄的血液动力学影响.
评估诸如墙壁剪切应力,流动振荡和内皮细胞激活等参数.

主要方法:

使用流体结构相互作用 (FSI) 方法.
从患者特定数据中采用半理想化的几何形状.
分析了墙壁位移,TAWSS,OSI,HOLMES和ECAP. 这些都是

主要成果:

在75%的狭窄时观察到峰值墙壁位移.
随着狭窄的严重程度,TAWSS的增加.
在非静脉和分叉区域增加的OSI.
低的HOLMES和高的ECAP在狭窄的下游表明血栓形成的风险.

结论:

动脉狭窄会导致下游血动力学显著变化.
患有流动干扰和高ECAP的静脉后区域存在血栓形成的风险.
在狭窄部位之外进行全面的血液动力学监测对于患者管理至关重要.

关键词:

流体的结构相互作用.血液动力学血液动力学腹动脉的腹动脉半理想化的几何形状.狭窄的严重程度狭窄的严重程度风模型风模型

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