多发性硬化症的关节动力学和步行模式:3D分析比较方法
Radu Rosulescu1,2, Mihnea Ion Marin3, Elena Albu4
1Department of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Bioengineering (Basel, Switzerland)
|October 29, 2025
概括
患有多发性硬化症 (MS) 的人表现出下肢 (LL) 运动控制的改变,脚受到影响最多. 步行分析显示运动控制受损,而不是结构性关节问题.
科学领域:
- 神经学 神经学
- 生物力学 生物力学
- 运动科学 运动科学
背景情况:
- 多发性硬化症 (MS) 是一种影响运动功能的神经退行性疾病.
- 走路不对称和改变关节动力学在患有多发性硬化症 (pwMS) 的人群中很常见.
研究的目的:
- 为了比较下肢 (LL) 行为,步态不对称和pwMS和健康对照之间的关节动力学.
- 确定受MS影响的特定关节参与和步行阶段.
主要方法:
- 横截面研究涉及15个 pwMS (EDSS ≤4.5) 和15个健康对照.
- 维康运动捕捉系统用于收集五个步态周期的动力学数据.
- 下肢关节的运动范围 (ROM) 和运动对称性的分析.
主要成果:
- 在pwMS中,脚是受影响最多的关节,其次是膝盖,而部没有显著差异.
- 摆动阶段与立场阶段相比,表现出更大的左右不对称性 (更高的RMSE).
- 在pwMS的完整步行周期中,没有观察到显著的左右关节不对称.
结论:
- 多发性硬化主要影响运动控制,损害关节之间的微调,而不是造成结构性关节损伤.
- 全球运动控制功能障碍,而不是孤立的关节不对称性,在MS中表征着步行障碍.
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