益生菌对焦虑和抑郁的雌激素作用:叙述性审查
Gilberto Uriel Rosas-Sánchez1,2, León Jesús Germán-Ponciano3, Juan Francisco Rodríguez-Landa3
1Programa de Estancias Posdoctorales por México, SECIHTI, Centro Universitario de Los Lagos, Universidad de Guadalajara, Lagos de Moreno 47460, Jalisco, Mexico.
International journal of molecular sciences
|October 29, 2025
概括
益生菌有望改善焦虑和抑郁症,特别是在经历激素变化的女性中. 需要进一步的研究来了解个体反应,并优化肠-大脑轴干预措施.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 焦虑和抑郁是全球普遍存在的精神健康障碍,在荷尔蒙波动期间不成比例地影响女性.
- 微生物群-肠-大脑轴 (MGB轴) 通过神经递质生产 (血清素,GABA,多巴胺) 和激素代谢参与情绪调节.
- 肠道微生物的雌激素作用,通过像β-glucuronidase这样的酶介导,影响情绪和荷尔蒙平衡.
研究的目的:
- 审查关于治疗焦虑和抑郁症的益生菌干预措施的临床前和临床证据,重点关注激素调节.
- 探索MGB轴在心理健康中的作用,特别是与雌激素效应和情绪障碍有关的作用.
- 鉴定基于益生菌的心理健康疗法的当前挑战和未来方向.
主要方法:
- 在科学数据库 (PubMed,ScienceDirect,Scopus,Web of Science) 中进行全面的文献搜索.
- 在动物模型中进行的临床前研究和对照性临床试验的选择,调查益生菌菌株及其雌激素效应.
- 排除缺乏全文访问的研究.
主要成果:
- 在雌性大鼠中进行的临床前研究表明,在服用益生菌后,与焦虑和抑郁相关的行为有显著的改善.
- 在特定人群的临床试验,包括更年期妇女和患有月经前综合征的妇女,产生了有希望的结果.
- 个人反应的变化和长期对照研究的需要被确定为重大挑战.
结论:
- 益生菌是治疗焦虑和抑郁症的有希望的途径,特别是当与荷尔蒙波动有关时.
- 个性化的益生菌方法和omics/神经成像技术的整合提供了未来的治疗潜力.
- 进一步控制的长期研究对于优化益生菌的疗效和在心理健康治疗中的应用至关重要.
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