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在良性乳腺疾病中的乳腺腺微生物群

Nikita I Ukraincev¹, Maria I Kashutina^1,2,3, Larisa I Kasatkina¹

¹Mammology Center, A.S. Loginov Moscow Clinical Scientific and Practical Center of the Moscow Healthcare Department, 111123 Moscow, Russia.

International journal of molecular sciences

|October 29, 2025

概括

微生物失衡或失调是良性乳腺疾病 (BBD) 的关键. 乳腺和肠道中的特定细菌可以作为BBD的诊断标记和治疗点.

科学领域:

微生物组研究的研究.
人类健康和疾病.
良性乳腺疾病是一种良性乳腺疾病.

背景情况:

人类微生物组显著影响健康和疾病.
虽然研究了乳腺癌 (BC) 和微生物群,但良性乳腺疾病 (BBD) 仍未得到充分探索.
了解BBD中的乳腺 (MG) 微生物群至关重要.

研究的目的:

综合当前关于MG微生物群组成,起源和BBD中的功能知识.
评估MG微生物群对新型诊断和治疗点的潜力.
为了识别与BBD相关的特定微生物特征.

主要方法:

对MG微生物群和BBD现有的文献进行叙述性审查.
对微生物组成和与宿主的功能相互作用的分析.
与健康对照相比,在BBD中识别出明显的微生物模式.

主要成果:

在BBD中观察到明确的MG微生物群模式,包括在粒状乳腺炎中*Corynebacterium kroppenstedtii*和在纤维腺瘤/乳房乳腺炎中*Staphylococcus aureus*的丰富.
在BBD患者中,肠道微生物的特定特征显示了增加的*Clostridium*和*Faecalibacterium*,以及减少的*Collinsella*和*Alistipes*.
已识别的微生物种群是诊断生物标记物的潜在候选人.

结论:

微生物失生症是BBD病变发生的一个重要因素.
需要进行多组学和机理学研究,以将研究结果转化为临床应用.
针对BBD特定的微生物组为新型诊断和个性化治疗提供了潜力.

关键词:

良性乳腺疾病是一种良性乳腺疾病.乳腺疾病乳腺疾病乳腺组织乳腺组织这种疾病叫做dysbiosis.哺乳腺的微生物群微生物组是一个微生物组.

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