怀孕和干眼综合征:临床实践的审查
Marta Jaruchowska1, Joanna Przybek-Skrzypecka2,3, Janusz Skrzypecki4
1ISPL Marta Jaruchowska, 13-200 Działdowo, Poland.
International journal of molecular sciences
|October 29, 2025
概括
怀孕可能会导致干眼综合征 (DES) 由于荷尔蒙变化,影响到50%的孕妇. 虽然症状通常是轻微的,但识别和管理DES对于母亲的舒适和眼睛健康至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 生殖医学 生殖医学
- 在怀孕期间生理适应.
背景情况:
- 怀孕涉及显著的荷尔蒙,代谢和免疫变化,影响眼睛表面平衡.
- 干眼综合征 (DES) 经常在怀孕期间观察到,可能与雌激素和孕激素波动,胰岛素耐药性和免疫耐受性有关.
- 虽然DES影响20-50%的孕妇,特别是在第二和第三个三个月,但其作为确定的危险因素的地位仍然不确定的.
研究的目的:
- 审查孕期DES的病理生理机制.
- 为经历DES的孕妇概述诊断策略和安全管理选项.
- 强调参与产前和眼科护理的医疗保健提供者对DES的认识的重要性.
主要方法:
- 对孕期DES的病理生理机制,诊断方法和管理策略的文献综述.
- 综合目前的证据和共识报告 (例如,TFOS DEWS III) 关于怀孕和DES之间的关系.
- 重点是临床影响和需要提高提供者意识.
主要成果:
- 荷尔蒙变化,特别是雌激素和孕激素,是妊娠期间DES发展或恶化的关键因素.
- 尽管DES症状往往是自我限制的,但它可能会对生活质量和产前护理的坚持产生负面影响.
- 目前的证据虽然在生物学上是可信的,但并不能最终确定怀孕是DES的确诊危险因素.
结论:
- 在怀孕期间增加DES的识别对于改善患者舒适度和预防潜在的长期眼部并发症至关重要.
- 产科医生和眼科医生之间的合作意识对于在孕妇患者中有效诊断和管理DES至关重要.
- 进一步的研究可能会澄清怀孕在DES病因和进展中的决定性作用.
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