红色复杂牙周病原体及其在结肠直肠癌发生中的潜在作用:叙述性综述
Ursa Potocnik Rebersak1,2, Rok Schara1,2
1Department of Oral Diseases and Periodontology, University Medical Center Ljubljana, 1000 Ljubljana, Slovenia.
International journal of molecular sciences
|October 29, 2025
概括
由"红色复合体"细菌驱动的牙周病与结直肠癌 (CRC) 有关. Porphyromonas gingivalis 感染与CRC进展和更差的预后有关,而其他红色复杂细菌促进炎症,支持瘤生长.
科学领域:
- 口腔微生物学 口腔微生物学
- 在瘤学瘤学.
- 炎症研究的研究.
背景情况:
- 牙周病 (PD) 是一种慢性炎症状况,与结直肠癌 (CRC) 等全身性疾病有关.
- 这是一个很棒的节目,这是一个很棒的节目.
- 红色复合体 红色复合体
- 细菌 (Porphyromonas gingivalis,Tannerella forsythia,Treponema denticola) 是PD的关键,并具有促进炎症和免疫逃避的毒性因素.
研究的目的:
- 对科学文献进行审查,研究两者之间的关联.
- 红色复合体 红色复合体
- 牙周病原体和结直肠癌. 牙周病原体和结直肠癌.
- 阐明这些细菌可能影响CRC发育和进展的机制.
主要方法:
- 在PubMed,谷歌学者和ScienceDirect进行了全面的文献搜索.
- 包括的研究是原始临床,体内或体外研究,发表于2025年9月之前.
- 重点是研究直接链接的研究.
- 红色复合体 红色复合体
- 致病原体对结肠直肠癌的作用.
主要成果:
- 大多数研究重点关注 Porphyromonas gingivalis,强调其在CRC免疫逃避,肠道微生物群改变,促炎微环境的创造和癌细胞增殖中的作用.
- Porphyromonas gingivalis 感染与较差的CRC预后有关.
- 其他 其他 其他
- 红色复合体 红色复合体
- 细菌有助于促进炎症的环境,支持瘤生长和生存.
结论:
- 牙周病的病原体,特别是 Porphyromonas gingivalis,与结直肠癌有显著的关联.
- 这些细菌可能通过涉及炎症,免疫调节和直接影响癌细胞的机制促进CRC.
- 需要进一步的研究,以充分理解口腔健康和结直肠癌之间的复杂相互作用.
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