向炎症:细胞子B调节了老鼠心脏中因伊马替尼布驱动的生物化学变化
Denise Börzsei1, András Nagy1, Viktória Kiss1
1Department of Physiology, Anatomy, and Neuroscience, Faculty of Science and Informatics, University of Szeged, H-6726 Szeged, Hungary.
International journal of molecular sciences
|October 29, 2025
概括
赛托斯波B (CsnB) 可能会保护心脏免受伊马替尼的化疗副作用. CsnB治疗减少了暴露于伊马替尼的老鼠心中的关键炎症和氧化标志物.
科学领域:
- 心血管药理学心血管药理学
- 自然产品化学 自然产品化学
- 瘤学 支持性护理 支持性护理
背景情况:
- 化疗可以改善癌症的存活率,但会引起心脏毒性.
- 探索天然化合物以减轻化疗不良影响.
- 伊马替尼布是一种具有已知的心血管风险的化疗剂.
研究的目的:
- 调查Cytosporone B (CsnB) 作为一种心脏保护剂,以防止因伊马替尼布引起的心脏毒性.
- 评估CsnB抗心脏炎症和因伊马丁尼布引起的氧化应激的能力.
主要方法:
- 雄性Wistar大鼠被分为对照组,Imatinib治疗组和Imatinib + CsnB治疗组.
- 鼠每天接受口服伊马替尼 (60毫克/公斤) 和/或腹腔内CsnB (5毫克/公斤) 两周.
- 对心脏组织进行了炎症标志物 (HMGB1,TNF-α,MPO,iNOS,PAD4) 和氧化应激 (NOX4) 的分析.
主要成果:
- 伊马替尼布治疗显著提高了心脏HMGB1,TNF-α,MPO,iNOS,PAD4和NOX4的调节.
- 同时治疗CsnB显著缓解了这些因伊马替尼引起的炎症和氧化标志物的升高.
- CsnB在对抗伊马替尼布诱导的心脏损伤方面发挥了重要作用.
结论:
- 赛托斯波B (CsnB) 显示出作为一种心脏保护剂的潜力,可以预防伊马替尼布诱导的心脏毒性.
- CsnB有效调节与伊马替尼不良心脏影响相关的炎症和氧化途径.
- 需要进一步的研究来探索CsnB在接受化疗的癌症患者的治疗应用.
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