结肠直肠癌的混杂调整差异化通过途径影响的动态传播
Larissa Margareta Batrancea1, Ömer Akgüller2,3, Mehmet Ali Balcı2
1Department of Business, Babeş-Bolyai University, 7 Horea Street, 400174 Cluj-Napoca, Romania.
International journal of molecular sciences
|October 29, 2025
概括
结肠直肠癌 (CRC) 根据瘤的位置显示出分子差异. 动态网络分析揭示了独特的时间模式和漏洞,指导左侧和右侧CRC的精密医学.
科学领域:
- 在瘤学瘤学.
- 计算生物学 计算生物学
- 系统生物学 系统生物学
背景情况:
- 大肠直肠癌 (CRC) 在左侧和右侧瘤之间表现出显著的分子异质性,影响治疗反应.
- 目前的基因组分析不足以捕捉影响CRC进展和治疗结果的动态功能差异.
研究的目的:
- 开发和应用一种新的计算框架,即动态功能影响计算 (DynaFIC),用于分析生物网络中的时间解析信号传播.
- 量化功能影响超出静态基因表达水平,以了解CRC横向性相关的分子差异.
主要方法:
- 用583个初级CRC样本的GSE39582数据集进行分析.
- 在105个横向相关基因上进行了混调整的差异表达分析和DynaFIC时间网络分析.
- 对微卫星不稳定性,BRAF突变,TNM阶段,年龄和性别进行控制.
主要成果:
- 右侧CRC瘤显示了更高的网络连接密度,HOXC6作为主导调节器,表明分布式漏洞.
- 左侧CRC瘤表现出一个等级组织,其中PRAC1作为主要调节器和独特的时间传播动力学.
- 右侧瘤显示出快速的信号和和更高的系统脆弱性,表明需要早期干预.
结论:
- 解剖位置是结直肠癌中一个关键的网络组织原则.
- 将时间动态纳入癌症网络分析揭示了左侧和右侧CRC之间的治疗相关差异.
- 这些发现支持开发针对CRC横向性的精准医学策略.
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