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不同表达的补充路径组件在不明原因的不孕症与男性因子不孕症的差异表达:从一个探索试点研究的见解

Edwina Brennan¹, Marya K E A Radhi¹, Zainab A A H Husain¹

¹School of Medicine, Royal College of Surgeons in Ireland Bahrain, Adliya 15503, Bahrain.

International journal of molecular sciences

|October 29, 2025

概括

与男性因子不孕症 (MFI) 患者相比,患有不明原因不孕症 (UI) 的女性表现出关键补充蛋白的水平降低,包括properdin,C3a,C4和C8. 这些发现表明,补充系统在UI中的失调可能起到作用.

科学领域:

免疫学免疫学免疫学
生殖医学生殖医学
蛋白质组学是指蛋白质组学.

背景情况:

补充蛋白质与生殖健康和不孕症有关.
无法解释的不孕不育 (UI) 缺乏明确的原因,这促使人们对新的因素进行调查.
补充系统在女性生殖道,特别是UI中的作用需要进一步阐明.

研究的目的:

调查补充蛋白与在体外受精 (IVF) 妇女中无法解释的不孕症 (UI) 的关联.
为了比较UI妇女的补充蛋白水平与男性因子不孕症 (MFI) 妇女的水平作为对照.
探索将补充因子与UI病理生理学联系起来的潜在机制.

主要方法:

试点研究涉及25名接受试管婴儿的妇女 (14 UI,11 MFI).
血样本采集于黄素阶段的第21天.
用于量化25种与补充通路相关的蛋白质的SOMA扫描试验.
统计分析包括学生的t测试和皮尔森的相关性.

主要成果:

在UI和MFI组之间,基线人口统计,荷尔蒙参数或试管婴儿反应没有显著差异.
与MFI组相比,在UI组中观察到明显较低的properdin (p=0.03),C3a阿纳菲拉托克辛des arginine (C3adesArg) (p=0.02),C4 (p=0.04) 和C8 (p=0.04) 的水平.
在UI组中,properdin与HDL-c负相关,C8与TSH和自由T3正相关 (p<0.05).

结论:

初步发现表明,在女性中补充活性减少,原因不明的不孕不育.
较低水平的特定补充蛋白可能会影响子宫内膜受体性,卵泡发育和血管性.
需要进一步的机制研究,以了解补充剂在UI中的失调作用.

关键词:

在C3adesArgg中使用.C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 在C8上,你会看到C8.补充路径是补充路径.不孕不育不孕不育不孕不育普罗佩尔丁是自己的.无法解释的不孕不育.

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