长期胰腺炎中母细胞,胰腺恒星细胞和白细胞:超结构性研究
Irina Chekmareva1,2,3, Andrey Kostin3, Oksana Paklina1,4
1Federal State Budgetary Institution "National Medical Research Center of Surgery Named after A.V. Vishnevsky" of the Ministry of Health of the Russian Federation, Bolshaya Serpukhovskaya St, 27, 115093 Moscow, Russia.
International journal of molecular sciences
|October 29, 2025
概括
乳腺母细胞和胰腺星状细胞被激活,而在胰腺纤维化中,小细胞被损伤. 这些细胞变化,特别是巨细胞脱粒和三细胞破坏,是慢性胰腺炎中纤维化发展的关键.
科学领域:
- 胃肠道学和细胞生物学
- 研究胰腺纤维化细胞机制.
背景情况:
- 胰腺纤维化,慢性胰腺炎 (CP) 的一个关键特征,涉及过度的细胞外基质 (ECM) 沉积.
- 导致胰腺纤维化的确切细胞相互作用和超结构性变化尚不清楚.
研究的目的:
- 检查胰腺纤维化不同程度的细胞间通信和巨细胞 (MCs),胰腺星状细胞 (PaSCs) 和三角细胞 (TCs) 的超结构性变化.
- 了解这些细胞和ECM在CP相关纤维化病原体中的作用.
主要方法:
- 对17名患者的手术胰腺组织进行了组织学,免疫组织化学 (IHC) 和电子显微镜 (EM) 分析.
- 针对CD34,CD117和SMA的抗体用于IHC,而光IHC用于CD34和CD117.
- 纤维化映射使用了QuPath软件,EM检查了超薄的截面.
主要成果:
- 在纤维化胰腺组织中,乳腺细胞 (MC) 活动和脱粒度增加,有细胞间接触的证据.
- 胰腺恒星细胞 (PaSCs) 显示出激活的迹象,包括超结构和功能变化.
- 太阳细胞 (TCs) 呈现不连续性,缩短的太阳足和核分裂,以及激活的外体运输.
结论:
- 增加的巨细胞活动和胰腺恒星细胞激活在胰腺纤维化中很突出.
- 细胞的破坏和相关的外体运输对慢性胰腺炎中纤维化病原有显著贡献.
- 这些细胞相互作用代表了治疗胰腺纤维化的潜在治疗点.
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