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用银和石纳米颗粒功能化的球 - - 对临床相关的细菌病原体具有抗菌活性

Marcin Gajek¹, Karolina Klesiewicz², Maria Biegun-Żurowska¹

¹Faculty of Materials Science and Ceramics, AGH University of Krakow, Av. Mickiewicza 30, 30-059 Krakow, Poland.

International journal of molecular sciences

|October 29, 2025

概括

混合纳米材料与银或珠纳米颗粒显示强大的抗菌活性,有效抑制*Helicobacter pylori*和其他细菌. 表面功能化增强了纳米粒子分布和杀菌效果,这表明生物医学和食品工业的应用.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
微生物学微生物学

背景情况:

新型抗菌剂的开发对于对抗细菌感染至关重要.
混合纳米材料为增强的治疗应用提供独特的特性.
球提供了一个多功能平台,用于结合抗微生物纳米颗粒.

研究的目的:

合成和表征含有银纳米粒子 (AgNPs) 或米纳米粒子 (BiNPs) 的基于的混合纳米材料.
评估这些纳米材料的抗菌疗效与包括Helicobacter pylori*在内的格兰阳性和格兰阴性细菌的小组对比.
研究表面功能化 (APTES) 对纳米粒子分布和抗菌活性的影响.

主要方法:

修改的斯托伯方法用于二氧化球合成.
在球上沉积AgNP或BiNP,有或没有APTES功能.
使用SEM,TEM,XRD,ICP-OES和泽塔电位测量的表征.
通过微稀释试验评估抗菌活性,以确定最小抑制度 (MIC) 和最小杀菌度 (MBC).

主要成果:

SiO2-AgNP和SiO2-BiNP复合物显示出完全抑制H. pylori的发生.
对大多数测试的病原体观察到高的抗微生物活性,其中P. aeruginosa表现出降低的敏感性.
APTES的功能化导致了AgNP的均分布和杀菌作用 (MBC/MIC比率1-4).
非功能化BiNP涂层样本的疗效较低,与无形阶段的Bi3+释放增加有关.

结论:

混合-纳米粒子复合材料具有显著的抗微生物潜力.
表面功能化在调节离子释放和提高生物性能方面发挥着关键作用.
这些纳米材料在生物医学和食品行业的应用方面表现有前途.

关键词:

抗微生物活性的抗微生物活性.比斯穆特纳米颗粒的使用方法石英球体中的二氧化银纳米颗粒的使用方法

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