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Updated: Jan 13, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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在血管炎症和动脉样硬化期间,KLF4,STAT,IRF和NF-κB在VSMC和巨细胞可塑性之间的相互作用

Natalia Lopacinska1, Joanna Wesoly2, Hans A R Bluyssen1

  • 1Human Molecular Genetics Research Unit, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, 61-614 Poznan, Poland.

International journal of molecular sciences
|October 29, 2025
PubMed
概括

克鲁佩尔样因子4 (KLF4) 调节动脉样硬化中的血管光滑肌细胞 (VSMC) 和巨细胞 (MØ) 的可塑性. 了解KLF4,STAT,IRF和NF-κB相互作用为血管疾病提供了新的治疗点.

关键词:
干扰素调节因子 (IRF)干扰素玛 (IFNγ) 和托尔类受体 (TLR) 4信号传递.克鲁佩尔类因子4 (KLF4)核因子-κB (NF-κB) 是一个信号转换器和转录激活器 (STAT)血管光滑肌细胞 (VSMC) 和巨细胞的可塑性动脉样硬化 动脉样硬化转录网络是一种转录网络.

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