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使用半固体挤出3D打印洛萨坦片的开发和评估:几何学,药物负载和超级分解剂的影响
Aleksandra Vojinović1, Đorđe Medarević2, Gordana Stanojević1
1Institute for Medicines and Medical Devices of Montenegro, 81000 Podgorica, Montenegro.
Pharmaceuticals (Basel, Switzerland)
|October 29, 2025
概括
半固体挤出 (SSE) 3D打印成功生产了具有精确尺寸和可调节药物释放的洛萨坦片. 这种先进的制造技术对个性化医疗非常有希望,通过控制的配方和几何来优化平板电脑的性能.
科学领域:
- 制药技术 制药技术 制药技术
- 添加剂制造 添加剂制造 添加剂制造
- 药物输送系统 药物输送系统
背景情况:
- 半固体挤出 (SSE) 3D打印是一种灵活的方法,用于创建针对患者的口服剂型.
- 开发优化的SSE3D打印洛萨坦片需要评估聚合物组成,片剂设计,药物负载和超级分解剂水平.
研究的目的:
- 使用SSE3D打印来开发和优化洛萨坦片.
- 调查配方和设计变量对平板电脑打印能力和性能的影响.
主要方法:
- 评估基基甲基纤维素 (HPMC) 4500 在乙醇-水溶剂系统中适用于SSE打印.
- 有各种形状的打印片,洛萨坦含量 (5-15%) 和十字卡梅洛斯度 (0-3%).
- 用于尺寸准确性,质量均性,分解和药物释放的特征片;使用Korsmeyer-Peppas模型分析释放动力学.
主要成果:
- SSE 3D 打印平板显示出极好的尺寸精度 (SD < 0.8 mm) 和质量均性 (SD < 0.12 g).
- 增加药物负载加速释放率 (在15%负载下在45分钟内达到63%).
- 1%的十字糖将分解时间缩短到~25分钟;释放后的扩散控制动力学 (Korsmeyer-Peppas模型,R2>0.96).
结论:
- SSE 3D 打印是一种强大且适应性强的技术,用于制造具有一致质量的洛萨坦片.
- 该研究强调了通过配方和设计修改来调整药物释放配置文件的潜力.
- 简单的3D打印为推进个性化制药制造提供了重要的机会.
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