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含有的混合体装载着布洛芬作为药物输送系统的模型

Yoanna Kostova¹, Pavletta Shestakova², Albena Bachvarova-Nedelcheva³

¹Institute of Metal Science, Equipment and Technologies with Hydro- and Aerodynamics Centre "Acad. A. Balevski", Bulgarian Academy of Sciences, Shipchenski Prohod Str., 67, 1574 Sofia, Bulgaria.

Pharmaceuticals (Basel, Switzerland)

|October 29, 2025

概括

这项研究开发了一种新的-聚乙烯 (Si-PVP) 纳米混合药物输送系统. 无形药物--有机聚合物相互作用增强了易布洛芬的溶解性和释放性,显示了药物输送的前景.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

混合材料为药物输送应用提供独特的特性.
对于封装活性药物成分的-聚乙烯 (Si-PVP) 系统进行了探索.
了解药物矩阵相互作用对于优化药物释放至关重要.

研究的目的:

为了合成和表征Si-PVP纳米混合物用于药物输送.
研究合成方法对药物封装和特性的影响.
评估纳米混合体作为布洛芬药物输送系统的潜力.

主要方法:

在环境温度下使用酸性催化剂合成Si-PVP纳米混合物的Sol-gel合成.
通过直接引入或溶剂沉积将布洛芬 (IBP) 纳入.
使用X射线衍射 (XRD),扫描电子显微镜 (SEM),红外 (IR) 光谱,UV-Vis光谱和固态核磁共振 (NMR) 的表征.

主要成果:

在Si-PVP网络中,XRD证实了无形易布洛芬.
SEM显示IBP颗粒的平均大小约为20微米.
光谱和核磁共振分析表明,ibuprofen,PVP和二氧化之间存在结合,在吸附剂中保留了晶体药物结构.
索尔凝方法导致无形药物,PVP和之间更明显的相互作用.

结论:

开发的Si-PVP纳米混合体证明了布洛芬的水溶性改善和体外药物释放.
与吸附剂相比,sol-gel合成的材料表现出更强的药物基因相互作用.
这种纳米混合体显示出作为先进的药物输送系统的巨大潜力.

关键词:

在体外的药物释放.二氧化 (聚) 乙烯 (乙烯) ibuprofen 纳米混合物这是一种sol-gel工艺.固态NMR是一种固态NMR.

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