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发生中的IL-1β和HMGB1:最近的进展和临床翻译

Huali Geng^1,2, Leihao Sha¹, Lei Chen^1,2

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.

Pharmaceuticals (Basel, Switzerland)

|October 29, 2025

概括

耐药性影响了许多患者. 针对IL-1β和HMGB1等神经炎症通路显示出希望,但缺乏临床治疗方法,凸显了研究和患者护理之间的差距.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

是一种流行的神经系统疾病,影响1%的人口.
耐药性会影响三分之一的患者,原因是复杂的病理生理学.
神经炎症是发作的关键因素,涉及IL-1β和HMGB1.1等途径.

研究的目的:

审查了解发生过程中的IL-1β/IL-1R1/IL-1Ra和HMGB1/TLR4通路的进展.
评估目前针对发症的这些炎症途径的干预研究.
弥合研究成果与治疗临床应用之间的差距.

主要方法:

临床前和临床研究的文献综述.
对中IL-1β/IL-1R1/IL-1Ra和HMGB1/TLR4通路的研究进行分析.
对针对这些途径的治疗干预措施的评估.

主要成果:

IL-1β和HMGB1通路在发发生过程中起着重要作用.
针对这些途径的干预措施在研究中显示出抗发作效应.
这些向治疗的临床转化仍然有限.

结论:

IL-1β和HMGB1通路代表了的有前途的治疗标.
研究进展和临床实施之间存在很大的差距.
需要制定战略,以加快针对神经炎症治疗的临床转化.

关键词:

这就是HMGB1的特点.在IL-1R中,IL-1R是最常见的.在IL-1β的研究中,IL-1β被认为是IL-1β.在 TLR4 中,临床翻译临床翻译是一种.治疗目标是治疗的目标.

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