青少年的长效注射抗精神病药物:从目前的证据和差距到临床实践
Simone Pardossi1, Alessandro Cuomo1, Giacomo Gualtieri2
1Department of Molecular Medicine, University of Siena School of Medicine, 53100 Siena, Italy.
Pharmaceuticals (Basel, Switzerland)
|October 29, 2025
概括
长效注射抗精神病药 (LAI) 对患有严重精神疾病的青少年来说是有前途的,改善了坚持和结果. 然而,有限的数据需要进一步的研究和仔细的临床监测,特别是同时出现的物质使用障碍.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 青少年健康 青少年健康
背景情况:
- 青春期是精神病等严重精神疾病的关键时期.
- 在青少年中,不坚持口服抗精神病药物很普遍,导致复发和功能衰退.
- 同时出现的物质使用障碍 (SUDs) 加剧了不坚持并恶化了临床结果.
研究的目的:
- 审查关于长效注射抗精神病药物 (LAI) 在青少年中的有效性和安全性的现有证据.
- 概述在这个人群中使用LAI的潜在临床实践建议.
- 确定当前关于18岁以下个体的LAI的研究中存在的差距.
主要方法:
- 进行了对科学文献的叙事审查.
- 根据抗精神病药物类别系统地组织证据,包括RISPERIDONE,PALIPERIDONE和ARIPIPRAZOLE的LAI.
- 对疗效,安全性和临床结果的数据进行了综合.
主要成果:
- 在青少年中使用LAI的证据有限且多样化.
- 特定的LAI在症状严重程度,功能和减少精神分裂症和双相情感障碍等疾病的住院治疗方面表现出好处.
- 常见的副作用包括EPS和高血;在某些特定情况下报告了非标签使用.
结论:
- 目前关于青少年LAI的数据稀少,没有确立的临床指南.
- 在特定的青少年病例中,在仔细监测和心理社会支持下,可以考虑非标签的LAI使用.
- 迫切需要进行前性,受控研究,以确认该人群的长期疗效和安全性,特别是同时发生的SUDs.
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