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预后免疫和营养指数作为切除非小细胞肺癌生存的预测指标

Soomin An¹, Sehyun Kim², Wankyu Eo³

¹Department of Nursing, Dongyang University, Gyeongbuk 36040, Republic of Korea.

Medicina (Kaunas, Lithuania)

|October 29, 2025

概括

预后免疫和营养指数 (PINI) 是接受手术的非小细胞肺癌 (NSCLC) 患者整体生存的有价值预测指标. 纳入PINI可以改善个性化患者评估的预后模型.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
营养科学营养科学

背景情况:

预后免疫和营养指数 (PINI) 显示了胃肠道癌症的预后价值.
它在非小细胞肺癌 (NSCLC) 的实用性需要进一步研究.

研究的目的:

评估PINI对I-IIIA阶段NSCLC患者的整体存活期 (OS) 的预后意义.
评估结合PINI的预后模型的性能.

主要方法:

对522名接受治疗意图切除的NSCLC患者进行了回顾性队列研究.
考克斯的比例危险模型来评估PINI与OS的关联.
模型性能使用C指数,IAUC,cnri和IDI进行评估.

主要成果:

在多变量分析中,PINI独立预测了OS.
包括PINI在内的完整模型 (FM) 的表现明显超过了基线 (BM) 和中间 (IM) 模型.
FM表现出优越的风险重新分类和良好的校准.

结论:

皮尼作为可切除NSCLC的独立和临床显著的预后生物标志物.
整合PINI可以提高预后准确性,并有助于个性化风险评估.
为了更广泛的适用性,建议进行外部验证.

关键词:

免疫力是一种免疫力.非小细胞肺癌的肺癌.营养状态营养状况肺部外科手术手术的过程.

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