马拉松跑者的急性损伤生物标志物:系统性审查和元分析
Daniel-Corneliu Leucuța1, Loredana-Ioana Trif1, Oana Almășan2
1Department of Medical Informatics and Biostatistics, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Medicina (Kaunas, Lithuania)
|October 29, 2025
概括
马拉松跑步在比赛结束后立即显著提高损伤生物标志物. 马拉松后出现不同的生物标志物模式,其中一些在24小时后仍然升高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 运动生理学 运动生理学
- 生物标志物研究 生物标志物研究
背景情况:
- 马拉松跑是一项艰苦的体力活动.
- 急性损伤 (AKI) 可能发生在运动员身上.
- 了解马拉松后脏生物标志物的变化至关重要.
研究的目的:
- 测量马拉松前,马拉松后,马拉松后24小时内脏生物标志物的变化.
- 为了确定潜在的生物标志物来诊断运动诱导的AKI.
- 描述这些生物标志物的时间动态.
主要方法:
- 对马拉松跑者和AKI生物标志物的研究进行系统审查和随机效应元分析.
- 纳入标准:研究报告了马拉松跑步者的AKI相关生物标志物.
- 搜索的数据库:PubMed,EMBASE,科学网,LILACS. 这些数据库中的一个是: 使用NHLBI预后工具评估偏差风险.
主要成果:
- 与基线相比,大多数脏生物标志物在马拉松后立即显著增加.
- 观察到的显著增加是组织抑制物金属蛋白酶-2*胰岛素类生长因子结合蛋白-7 (TIMP-2*IGFBP),素,尿液肝型脂肪酸结合蛋白 (L-FABP),尿液单细胞化学吸引蛋白-1 (MCP-1),IGFBP-7,尿液胆酶3类蛋白-1 (YKL-40),和TIMP-2.
- 确定了生物标志物进化的明显时间模式,其中一些在比赛后24小时仍然升高.
结论:
- 马拉松跑步导致损伤生物标志物的显著升高.
- 特定的生物标志物如TIMP-2*IGFBP,copeptin,L-FABP,MCP-1,IGFBP-7,YKL-40和TIMP-2在运动员中显示出AKI诊断的前景.
- 马拉松后生物标志物的动态变化为脏压力和恢复提供了洞察力.
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