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上部胃肠切除后肠道微生物群的变化:我们是否应该实施查以预防并发症?
Urška Novljan1,2, Žan Bohinc2, Niko Kaliterna3
1General Hospital Novo Mesto, 8000 Novo Mesto, Slovenia.
Medicina (Kaunas, Lithuania)
|October 29, 2025
概括
小肠细菌过度生长 (SIBO) 影响了上部肠道手术后31%的患者,特别是在代谢手术后. 辅助放射/化疗和广泛的肠切除增加了SIBO风险,需要改进诊断.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 腹部外科 腹部外科
背景情况:
- 胃肠道 (GI) 手术增加了小肠细菌过度生长 (SIBO) 的风险,影响了恢复.
- 上部胃肠道外科手术后SIBO的患病率和临床意义尚不清楚.
研究的目的:
- 在各种上部肠道外科手术中评估SIBO的患病率.
- 确定与手术后SIBO发展相关的临床因素.
主要方法:
- 对157名有各种上部胃肠道手术病史的患者进行观察性研究.
- 用于SIBO诊断的葡萄糖-气呼吸试验.
- 收集的人口,临床和治疗数据;进行统计分析.
主要成果:
- 31%的患者在中位数为25.7个月的随访期内检测出SIBO阳性.
- 在Roux-en-Y胃绕道 (RYGB) 和单次解肠胃绕道 (OAGB) 后观察到的最高SIBO患病率为43%.
- SIBO与胀气,胀气,乳糖不耐受,全身性硬化症,T2D和辅助放射/化疗相关;风险随着肠道切除/排除程度的增加而增加.
结论:
- 在上部胃肠道手术后,SIBO的患病率为31%,在代谢手术患者中达到43%.
- 辅助性放射/化疗和广泛的小肠切除/排除显著增加了SIBO风险.
- 诊断敏感性/特异性的局限性强调了早期查和标准化诊断技术的必要性,以改善患者的治疗结果.
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