神经内分泌新生体中的瘤生长率:治疗策略的额外工具?
Roberta Modica1, Alessia Liccardi1, Elio Benevento1
1Endocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, 80131 Naples, Italy.
Medicina (Kaunas, Lithuania)
|October 29, 2025
概括
瘤生长率 (TGR) 在监测神经内分泌瘤 (NENs) 方面表现有前途. 这种动态参数可能会改善在NEN患者中超出标准RECIST 1.1标准的治疗评估.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 神经内分泌瘤 (NENs) 是一种罕见的瘤,具有复杂的生物学和多种治疗方法.
- 在NEN中准确评估治疗反应是具有挑战性的.
- 目前的RECIST 1.1标准已经确认了NEN评估的局限性.
研究的目的:
- 审查瘤生长率 (TGR) 在评估神经内分泌瘤中的作用和实用性.
- 探索TGR作为一个动态参数,以补充NENs的传统成像标准.
主要方法:
- 对评估神经内分泌瘤瘤生长率 (TGR) 的研究进行了综述.
- 分析TGR计算,包括TGR0 (12-24周) 和TGR3m (3个月).
- 在不同的NEN等级中,TGR与无进展生存 (PFS) 的相关性.
主要成果:
- 在G1和低G2NEN中,TGR评估 (TGR0和TGR3m) 与无进展生存 (PFS) 相对相关性很好.
- 确定了特定的TGR截止值:TGR0的4%/月和TGR3m的0.8%/月在相关的NEN亚型中.
- TGR提供了超越静态RECIST测量的瘤动力学的洞察力.
结论:
- 瘤生长率 (TGR) 在神经内分泌新生瘤中提供了宝贵的预后信息.
- 对于NEN患者来说,TGR可能会改进治疗监测策略.
- 需要进一步的前性研究来确定TGR作为NEN管理的标准临床工具.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...