预测创伤患者急性损伤的生物标志物
In Sik Shin1, Myoung Jun Kim2, Da Kyung Kim3
1Division of Acute Care Surgery, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of Korea.
Medicina (Kaunas, Lithuania)
|October 29, 2025
概括
血红蛋白和尿层线粒体DNA拷贝数 (mtDNAcn) 可以预测创伤患者的急性损伤 (AKI). 使用这些生物标志物的早期检测AKI可能会改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 创伤医学 创伤医学
- 生物标志物发现发现
背景情况:
- 急性损伤 (AKI) 是创伤患者经常出现的并发症,导致发病率和死亡率增加.
- 早期识别 AKI 风险患者对于及时干预和改善结果至关重要.
- 尿层线粒体DNA拷贝数 (mtDNAcn) 是AKI的潜在生物标志物,但其在创伤患者中的作用尚未得到研究.
研究的目的:
- 评估尿动线粒体DNA拷贝数 (mtDNAcn) 作为创伤患者急性损伤 (AKI) 的早期预测因素的实用性.
- 评估基线血红蛋白 (Hb) 水平与该队列中AKI的发展之间的关联.
主要方法:
- 这是一项前性观察性研究,涉及65名创伤患者.
- 在基线和入院后24,48和72小时收集血清和尿液样本.
- 使用实时聚合酶链反应 (PCR) 测量尿液和血清mtDNAcn,并记录包括Hb水平在内的临床变量.
主要成果:
- 25名 (38.5%) 患者发生AKI.
- 患有AKI的患者在入院时Hb水平显著降低,尿液mtDNAcn水平较高.
- 多变量分析确定了低Hb和升高的尿 mtDNAcn作为AKI的独立预测因素,Hb的最佳切割值为10.95g/dL,尿 mtDNAcn的最佳切割值为738.0副本/μL.
结论:
- 血红蛋白 (Hb) 和尿层线粒体DNA拷贝数 (mtDNAcn) 是创伤患者早期AKI检测的独立生物标志物.
- 这些发现表明,在创伤人群中改善AKI风险分层的潜力.
- 需要进一步的多中心研究来验证这些生物标志物并确定最佳目标.
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