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固体Tranilast纳米晶装载离子隐形眼镜,用于持续的眼部药物输送
Shinichiro Kobayakawa1, Toru Matsunaga2, Hiroko Otake3
1Department of Ophthalmology, Nippon Medical School, Musashi-Kosugi Hospital, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Kanagawa, Japan.
Pharmaceutics
|October 29, 2025
概括
装有tranilast (TRA) 的新型隐形眼镜可提供持续的药物输送,改善眼部疾病的生物可用性和患者遵守性. 这种创新方法克服了传统眼液的局限性.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 传统的眼滴面临着有限的生物可用性和患者遵从性的挑战.
- 需要持续的药物输送系统来改善眼部疾病的治疗.
- 隐形眼镜为增强药物输送提供了一个潜在的平台.
研究的目的:
- 开发和评估用于持续药物释放的装有tranilast (TRA) 的隐形眼镜 (CL).
- 评估一种新的高温,高压 (hThP) 药物加载方法的有效性.
- 为了比较从阴性CLs与非离子和离子CLs的药物输送.
主要方法:
- 晶 (TRA) 纳米晶体是使用珠子研磨来制备的.
- 装有TRA的CLs是使用固体TRA纳米晶体和hThP方法制造的.
- 在子模型中评估了药物加载,释放动力学和眼睛安全性.
主要成果:
- 珠子研磨产生了尺寸为35-180纳米的TRA纳米粒子 (STN).
- 用STN和hThP方法制备的阴离子CL显示出更高的TRA负载和持续释放.
- 带有TRA的阴阳性CLs证明了持续向液和水性幽默输送,没有对眼睛的毒性.
结论:
- 使用STN的hThP方法增强了TRA加载和持续释放在阴性CLs中.
- 这种方法克服了传统方法的局限性,例如药物摄入量低和突发释放.
- 带有TRA的阴性CLs是改善眼部药物输送的有希望的策略.
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