基于纳米载体的聚合物药物配方,用于增强鼻至大脑输送
Tobeka Naki1, Sijongesonke Peter1, Sibusiso Alven2
1Department of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa.
Pharmaceutics
|October 29, 2025
概括
纳米载体为向大脑输送药物提供了一个有希望的解决方案,克服了血脑屏障 (BBB). 这种方法增强了用于神经疾病治疗的鼻至脑药物输送.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 生物材料和药物输送
背景情况:
- 神经系统疾病的治疗具有挑战性,因为血脑屏障 (BBB) 限制了药物进入.
- 传统的药物输送方法难以在大脑中达到治疗度.
研究的目的:
- 探索基于纳米载体的策略,以提高鼻至脑药物输送.
- 解决BBB在治疗神经系统疾病方面的局限性.
主要方法:
- 对纳米载体配方的审查,包括聚合物纳米载体.
- 研究改善药物透性,粘膜凝固和向的策略.
- 专注于通过细胞透来提高特异性的功能化.
主要成果:
- 纳米载体显示出促进活性化合物的鼻腔系统和大脑输送的潜力.
- 聚合物纳米载体保护药物,增加透性,改善粘膜粘合.
- 功能化增强了治疗分子向大脑细胞传递的特异性.
结论:
- 基于纳米载体的治疗剂对于提高鼻至脑输送系统的有效性至关重要.
- 这种方法提供了一个有希望的策略,以克服神经治疗的BBB挑战.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.艾滋病病毒 艾滋病病毒 艾滋病病毒帕金森氏症和亨廷顿氏症的疾病.血脑屏障 血脑屏障 血脑屏障 血脑屏障癌症 癌症 癌症 癌症 癌症纳米载体的纳米载体聚合物是一种聚合物.更多相关视频
15:04Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
11.4K
05:28A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System
Published on: August 15, 2019
25.2K
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
708
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
708
01:27Bioavailability Enhancement: Drug Permeability Enhancement
183
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
183
01:16Drug Delivery: Overview
718
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
718
01:18Drug Delivery: Enteral Route
1.6K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.6K
01:16Bioavailability Enhancement: Drug Solubility Enhancement
212
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
212
01:18Additional Routes of Drug Administration
4.6K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.6K