维生素D纳米脂质体改善溶解性,稳定性和通过肠道屏障的吸收
Cosimo Landi1, Elisa Landucci2, Costanza Mazzantini2
1Department of Chemistry, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.
Pharmaceutics
|October 29, 2025
概括
维生素D (VD) 纳米脂质体提高了溶解性和稳定性,TPGS结合纳米脂质体 (LPT-VD) 显示出卓越的性能. 这些增强的纳米载体为维生素D应用提供了更好的口服输送和细胞吸收.
科学领域:
- 制药科学 制药科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 维生素D (VD) 对骨健康至关重要,并且在免疫力和癌症治疗中发挥着新兴的作用.
- 血管疾病的脂友性质限制了其溶解性,吸收性和稳定性.
- 开发稳定和生物可利用的VD配方是必不可少的.
研究的目的:
- 开发和描述两种类型的纳米脂质体用于维生素D (VD) 输送:常规的 (LP-VD) 和与D-α-托科菲林聚乙烯甘氨酸1000酸盐 (TPGS,LPT-VD) 结合的.
- 评估已开发的纳米脂质体的物理,化学和胃肠道稳定性,溶解特征和Caco-2细胞吸收.
- 评估TPGS在增强VD稳定性和生物可用性的潜力.
主要方法:
- 封装VD的LP-VD和LPT-VD纳米脂质体的配方.
- 纳米脂质体的表征包括大小,多分散性指数 (PdI),Zeta潜力 (ZP) 和封装效率 (EE%).
- 评估储存稳定性,胃肠道稳定性,溶解概况和Caco-2细胞吸收.
- 纳米脂质体的冷化,然后封装在硬凝囊中,用于口服剂型模拟.
主要成果:
- 无论是LP-VD还是LPT-VD,都显示出高的封装效率 (约. 96-98%) 和改善的VD溶解度.
- 与LP-VD (85.50 nm) 相比,LPT-VD的粒子尺寸更小 (61.70 nm).
- 两种配方都显示出增强的储存和胃肠道稳定性,冷干燥产品保持参数28天.
- 与LP-VD相比,LPT-VD显示出更好的溶解特征和更高的Caco-2细胞吸收率.
结论:
- 纳米脂质体有效地提高了维生素D的可溶性,稳定性和溶解特征.
- 在LPT-VD中TPGS的结合显著改善了纳米脂质体的特性,包括稳定性和细胞吸收.
- LPT-VD显示出作为有效的口服维生素D输送系统的潜力,利用TPGS进行稳定和生物增强.
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