药物利用和药物坚持:对在亚托皮性皮肤炎中应用的具有不同施用途径的药物的数据驱动分析
Sara Mucherino1,2,3, Annunziata Raimondo4, Milana Krstin1
1Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
对亚托邦性皮肤炎 (AD) 的药物坚持因治疗而异. 杜皮卢马布注射的持久性比塔克罗利斯药膏更高,突出了影响患者坚持治疗的因素.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物坚持对于管理慢性疾病,如阿托皮性皮肤炎 (AD) 至关重要.
- 现有研究经常使用综合数据,需要分析特定的坚持阶段,如启动和停止.
- 了解粘附驱动因素,特别是施用途径,对于优化AD治疗至关重要.
研究的目的:
- 为了评估中度至重度AD患者的药物坚持.
- 调查药物治疗特征,特别是服用途径,如何影响药物遵守.
- 为了比较局部塔克罗利斯和皮下杜皮卢马布治疗之间的粘附模式.
主要方法:
- 意大利821名新诊断的AD患者的回顾性观察研究 (2021年1月至2022年6月).
- 使用EMERGE指南评估药物坚持,重点关注6个月和12个月的治疗开始和停止.
- 统计分析包括奇平方测试和治疗持续时间的描述性统计数据.
主要成果:
- 塔克罗利斯膏 (38%) 与杜皮卢马布注射 (12%),非启动率更高,受杜皮卢马布初始医疗保健支持的影响.
- 6个月后,75.6%的杜皮卢马布患者持续治疗,而塔克罗利斯患者的这一比例为24.4%.
- 一年后,杜皮卢马布的持久性为68.7%,而塔克罗利斯的持久性为22.5%,杜皮卢马布的中位治疗持续时间明显更长 (4.4个月对2.6个月).
结论:
- 局部塔克罗利莫斯和皮下杜皮卢马布之间存在着显著的粘附差异,用于AD.
- 服用途径似乎是影响阿兹海默症患者服药的关键因素.
- 情境和行为因素可能在观察到的坚持差异中起作用.
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