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含有Salvia officinalis提取物和益生菌的酸微粒的配方和测试
Krisztina Bodnár1,2, Pálma Fehér1,2, Zoltán Ujhelyi2,3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, 4032 Debrecen, Hungary.
Pharmaceutics
|October 29, 2025
概括
这项研究开发了先进的酸盐微珠,用于Salvia officinalis提取物输送,增强其吸收和生物活性. 该配方还显示了益生菌效应,促进有益的肠道细菌生长.
科学领域:
- 药物输送系统 药物输送系统
- 自然产品化学 自然产品化学
- 生物技术是生物技术.
背景情况:
- 开发有效的天然提取物口服输送平台至关重要.
- 萨尔维亚 officinalis 提取物具有有价值的生物活性化合物.
- 挑战包括植物提取物的稳定性不佳和生物可用性低.
研究的目的:
- 为Salvia officinalis提取物创建一个先进的口服输送平台.
- 在酸盐微珠中将提取物与胰岛素和角质素共同封装.
- 评估配方的物理化学,生物和治疗潜力.
主要方法:
- 离子凝被用来制造酸盐-胰岛素-pectin微粒.
- 描述包括形态学,粒子大小,封装效率,胀和溶解研究.
- 在体外测试中评估了酶的稳定性,Caco-2细胞的透性,抗氧化和抗炎活性以及乳酸菌的生长.
主要成果:
- 微粒 (~275μm) 显示>90%的封装效率和~90%的胀.
- 对pH敏感,持续释放的S. officinalis成分观察到增强的酶稳定性.
- 改善了Caco-2细胞的透性,保持了抗氧化/抗炎作用,并促进了Lactobacillus的活力.
结论:
- 酸盐-胰岛素-pectin微粒为Salvia officinalis提取物提供了一个稳定,可控释放的系统.
- 该配方增强了肠道吸收,并保持了生物有效性.
- 该系统表现出益生菌的潜力,支持肠道健康和治疗应用.
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