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研究提高卡纳格利弗洛辛的溶解度和生物可用性,使用喷雾干燥技术,采用质量设计方法

Ji Ho Lee1, Seong Uk Choi1, Tae Jong Kim1

  • 1Department of Pharmaceutical Engineering, Gyeongsang National University, 33 Dongjin-ro, Jinju 52725, Republic of Korea.

Pharmaceutics
|October 29, 2025
PubMed
概括

喷雾干燥提高了卡纳格利弗洛辛 (CFZ) 的溶解性和生物利用性. 这种质量设计方法优化了固体分散 (SDs),改善了药物溶解和老鼠体内吸收.

关键词:
盒子Behnken设计设计可以使用Canagliflozin.药物动力学 药物动力学从设计开始的质量.固体分散的散发方式喷雾干燥 喷雾干燥

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