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Updated: Jan 13, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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怀孕期间埃斯基塔洛普拉姆剂量优化:一个PBPK建模方法

Seo-Yeon Choi1, Eunsol Yang2, Kwang-Hee Shin1,3

  • 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.

Pharmaceutics
|October 29, 2025
PubMed
概括

这项研究使用了基于生理学的药理动力学 (PBPK) 建模来预测孕妇和胎儿的埃斯基塔洛普拉姆暴露. 建议在怀孕期间服用20毫克的每日剂量是最优的,考虑到妊娠阶段和CYP2C19代谢.

关键词:
在CYP2C19中.埃斯基塔洛普拉姆 (escitalopram) 是一种药物.基于生理学的药物动力学.怀孕 怀孕 怀孕 怀孕 怀孕

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