持续释放的内关节药物输送:临床环境中的PLGA系统和不断变化的策略
Jun Woo Lee1, Ji Ho Park1, Geon Woo Yu1
1College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan 330-714, Chungnam, Republic of Korea.
Pharmaceutics
|October 29, 2025
概括
长期释放的聚乳糖糖酸 (PLGA) 系统提供延长的关节内 (IA) 输送,减少注射频率. 本综述涵盖了PLGA降解,生物制剂的挑战和临床皮质类固醇仓库的成功,突出显示了未来的需求.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 类风湿病学 类风湿病学
背景情况:
- 关节内 (IA) 疗法通常需要频繁注射.
- 聚乳糖糖酸 (PLGA) 微球为IA输送提供持续释放.
- 了解PLGA降解及其对药物释放的影响对于关节治疗至关重要.
研究的目的:
- 审查目前对PLGA降解和释放动力学在关节内环境中的理解.
- 调查延长释放性皮质类固醇储存和其他药物的新兴平台的临床经验.
- 确定基于PLGA的IA交付的挑战和缓解策略,特别是蛋白质和疗法.
主要方法:
- 文献综述综合了PLGA降解,关节内释放行为和临床结果的数据.
- 对PLGA系统与非PLGA持续释放方法进行比较分析.
- 使用PLGA微球来检查蛋白质和的配方策略.
主要成果:
- PLGA微球可以延长关节停留时间,减少像皮质类固醇这样的疗法注射频率.
- 降解PLGA微球中的酸性微环境对蛋白质和的稳定性和释放提出了挑战.
- 临床数据显示,单剂量皮质类固醇储存可长时间缓解症状,但需要重复剂量安全性和更广泛的指示扩展.
结论:
- 基于PLGA的系统显示出延长IA药物递送的前景,对皮质类固醇有证明的疗效.
- 克服与蛋白质/聚和释放动力学相关的挑战需要先进的配方和制造策略.
- 进一步的多中心试验,强有力的质量控制和药物监测对于PLGA IA疗法的更广泛的临床采用和转化至关重要.
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