根据直肠癌患者的益生菌摄入量,肠道微生物组的变化 进行转向性胃修复:研究协议
Hyeung-Min Park1, Jaram Lee1, Soo Young Lee1
1Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, Republic of Korea.
Journal of clinical medicine
|October 29, 2025
概括
这项试点研究调查了益生菌如何影响直肠手术和口腔修复后患者的肠道细菌. 结果将澄清益生菌对功能障碍结肠的影响.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 手术瘤学手术瘤学
背景情况:
- 直肠癌手术往往需要转移口腔,导致结肠失生症.
- 益生菌补充剂对肠道微生物群在结节管修复后的影响尚未得到充分证实.
- 了解这些变化对于患者的康复和整体健康至关重要.
研究的目的:
- 为了确定口服益生菌 (共生菌) 摄入对静止结肠肠道微生物群组成的影响,在转移口腔修复后.
- 为了研究手术后肠道微生物多样性和结构的变化,有或没有益生菌干预.
主要方法:
- 一项前性,单中心,并行试点研究,涉及20名接受直肠癌手术的患者,用转向口腔.
- 患者被随机分配,接受共生菌或没有益生菌后口腔修复.
- 在肠切除前,口腔修复后立即收集便样本,并在修复后3周收集便样本进行16SrRNA测序和多样性分析.
主要成果:
- 对α和β多样性的分析将揭示微生物社区的变化.
- 协生菌和对照组之间的比较将确定特定的微生物转移.
- 这项研究旨在提供关于这种患者队列中益生菌疗效的定量数据.
结论:
- 这项研究代表了第一个前性试验,在转移口腔修复后检查益生菌对休息结肠微生物群的影响.
- 预计这些发现将阐明益生菌在这种临床环境中控制肠道失调症中的作用.
- 这项研究将为患者的未来治疗策略提供信息.
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