18-36个月的韩国儿童的孕前血糖状况和成长延迟:一个基于人口的研究
Eun-Jung Oh1, Yeeun Han2, Tae-Eun Kim3
1Department of Family Medicine, Konkuk University Medical Center, Chungju Hospital, Konkuk University School of Medicine, Chungju 27376, Republic of Korea.
母亲妊娠前糖尿病 (DM) 和禁食葡萄糖 (IFG) 损害与儿童的增长延迟有关. 在怀孕前优化母亲的血糖控制对于健康的儿童发育至关重要.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 孕前母亲的血糖状况是影响胎儿发育和长期儿童健康的关键因素.
- 了解母亲高血糖和后代生长之间的关联对于早期干预策略至关重要.
- 全国范围的健康查数据为调查人口层面的健康趋势提供了一个强大的平台.
研究的目的:
- 评估母亲怀孕前血糖状况 (正常,禁食葡萄糖受损,糖尿病) 与后代生长延迟之间的关联.
- 评估母亲高血糖症对儿童视觉和听觉发育的影响.
- 为了确定与母亲血糖控制相关的儿童发育延迟的潜在风险.
主要方法:
- 在2014年至2021年间出生的258,367名母婴双胞胎的回顾性队列分析.
- 母亲血糖状况的分类:正常 (<100 mg/dL),禁食葡萄糖受损 (IFG,100-125 mg/dL),糖尿病 (DM,≥126 mg/dL). 母亲血糖状况的分类:正常 (<100 mg/dL),禁食葡萄糖受损 (IFG,100-125 mg/dL),糖尿病 (DM,≥126 mg/dL).
- 增长迟缓定义为身高,体重,头周长的第10百分位以下;视觉/听觉发育通过问卷进行评估;计算权重相对风险 (RRs).
主要成果:
- 增长迟缓的发生率:3.5% (身高),3.8% (体重),4.3% (头周长). 视觉/听觉问题报告在1.2%和8.2%的儿童中.
- 无论是DM (1.2%) 还是IFG (9.3%) 组,在评估的年龄段中,后代的生长延迟风险增加.
- 孕产妇高血糖明显与后代的视觉和听觉发育有关,观察到年龄和时期的特定差异.
结论:
- 孕前母亲的血糖状况与韩国18-36个月的儿童的增长延迟有显著的关联.
- 这项研究强调了在怀孕前优化孕产妇血糖控制的重要性.
- 在怀孕前有效的血糖管理对于促进儿童发育的良好结果和预防生长延迟至关重要.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
05:44Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
相关概念视频
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Type 2 and Gestational
Inborn Errors of Metabolism
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Diabetes: Symptoms, Diagnosis, and Complications
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
