延迟的移植功能及其持续时间作为中期脏移植结果的预测因素:东欧中心的一项回顾性队列研究
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Oana Antal1,2, Tudor Moisoiu2,3, Robert Simon1,2,4
1Department of Anesthesia and Intensive Care, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Journal of clinical medicine
|October 29, 2025
概括
移植后延迟的移植功能 (DGF) 显著降低了移植和患者的存活率. 由于DGF,长期需要置换疗法 (RRT) 表明预后较差,强调其对长期结果的影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 临床结果研究研究
背景情况:
- 延迟移植功能 (DGF) 是一个重要的移植后并发症,影响存活率.
- 关于东欧人群中DGF的数据有限,特别是关于其严重程度的预后值.
- 置换疗法 (RRT) 持续时间对DGF结果的影响需要进一步定义.
研究的目的:
- 分析罗马尼亚成年移植接受者的DGF发病率和结果.
- 研究由RRT持续时间定义的DGF严重程度与患者/移植存活率之间的关联.
- 评估DGF在东欧大规模移植中心的预后意义.
主要方法:
- 对479名已故成年捐赠者 (DBD) 移植 (2017-2024) 的回顾性分析.
- DGF定义为移植后7天内需要透析;严重程度按RRT持续时间分层 (>14天 vs. ≤14天).
- 通过卡普兰-梅尔曲线,日志等级测试和对功能的eGFR评估结果.
主要成果:
- DGF发生在28.8%的接受者中,与较高的BMI,并发病率和较差的捐赠质量 (KDPI) 相关.
- DGF显著降低了1,3年和5年的移植存活率,以及3年和5年的患者存活率.
- 较长的RRT持续时间 (>14天) 与逐渐恶化的移植和患者生存结果相关.
结论:
- 延迟的移植功能是减少长期移植和移植后患者存活率的重要预测因素.
- 在DGF患者中,延长RRT持续时间是与更差的预后相关的关键因素.
- 这些发现强调了管理和监测DGF严重性的重要性,以改善移植结果.
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