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尽管在良性瘤中共享MED12突变,但组织特异性基因组进化

Jeong Namkung1, Sang Ho Park2, Ayoung Hwang3

  • 1Department of Obstetrics and Gynecology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 1021 Tongil-ro, Eunpyeong-gu, Seoul 03312, Republic of Korea.

Journal of clinical medicine
|October 29, 2025
PubMed
概括

子宫乳腺瘤 (ULs) 和乳腺纤维腺瘤 (FA) 分享了最初的MED12突变,但在基因组进化中存在分歧. ULs显示染色体不稳定性,而FA则发展出突变表型,影响瘤生物学和风险分层.

关键词:
在MED12中发生的突变.乳腺纤维腺瘤 乳腺纤维瘤在子宫的leiomyomaoma.整体外因子测序的测序

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