早期慢性胰腺炎的EUS剪切波测量:使用2019年JPS标准进行回顾性诊断准确性研究
Muneo Ikemura1, Yusuke Takasaki1, Koichi Ito1
1Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Journal of clinical medicine
|October 29, 2025
概括
内镜超声波切割波测量 (EUS-SWM) 显示早期慢性胰腺炎 (eCP) 患者的硬度较高. 这种技术可以作为评估eCP进展和纤维化的客观生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 纤维化评估的评估
背景情况:
- 慢性胰腺炎 (eCP) 的早期诊断对于预防疾病进展至关重要.
- 内镜超声波 (EUS) 对于eCP诊断至关重要,但在评估进展方面存在局限性.
- 通过EUS剪波测量 (EUS-SWM),可以准确量化组织硬性和纤维化.
研究的目的:
- 评估EUS-SWM在识别早期慢性胰腺炎 (eCP) 的诊断实用性.
- 为了将EUS-SWM值与已建立的eCP的EUS发现相关联.
- 评估EUS-SWM作为eCP进展的潜在生物标志物.
主要方法:
- 对38名接受EUS-SWM的患者进行了回顾性单中心研究.
- 根据2019年日本胰腺学会 (JPS) eCP标准对患者进行分类.
- 在eCP和非eCP组之间比较EUS-SWM值;与EUS发现进行相关性分析.
主要成果:
- 11名患者符合eCP的标准.
- 在eCP组中观察到明显更高的EUS-SWM值 (2.39 ± 0.54对1.84 ± 0.46,p=0.0065).
- EUS-SWM值与EUS阳性发现数量之间的正相关性 (r=0.62,p<0.001);AUC为0.78.
结论:
- 在eCP发现的患者中,EUS-SWM值显著升高.
- EUS-SWM与基于EUS的eCP诊断标准有很强的相关性.
- EUS-SWM显示出作为评估eCP及其进展的客观生物标志物的潜力.
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