严重喘患者的骨质疏松症:来自意大利严重喘网络 (SANI) 注册表的数据
Manuela Latorre1, Giulia Costanzo2, Andrea Giovanni Ledda2
1Pulmonary Unit, UOC Pneumologia Nord, Toscana Nord Ovest, Nuovo Ospedale Apuano, 54100 Massa, Italy.
Journal of clinical medicine
|October 29, 2025
概括
骨质疏松症在严重喘患者中很常见,与皮质类固醇使用和炎症有关. 像生物制剂这样的治疗方法可以降低风险并改善结果.
科学领域:
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
- 骨健康 骨健康 骨健康
背景情况:
- 严重的喘会增加骨质疏松症的风险,原因是慢性皮质类固醇使用和炎症.
- 国际注册表显示,严重喘中骨质疏松症的流行率显著,因治疗和护理优化而有所不同.
研究的目的:
- 在SANI注册表中评估使用单克隆抗体 (mAbs) 和/或长效肌抗体 (LAMAs) 的严重喘患者的骨质疏松症患病率.
- 通过比较患有骨质疏松症和没有骨质疏松症的患者特征来确定骨质疏松症的危险因素.
主要方法:
- 对接受第5步GINA治疗 (mAbs,LAMAs) 的1813名患者的分析.
- 骨质疏松症患者和没有骨质疏松症患者之间的人口,临床和治疗特征的比较.
主要成果:
- 在15.5% (282/1813) 的患者中发现骨质疏松症.
- 女性 (20.3%) 与男性 (8.0%) 的患病率更高,随着年龄和喘持续时间的增加而增加.
- 骨质疏松症与较差的喘控制,降低的肺功能 (FEV1,FVC),更多的恶化和较高的慢性口服皮质类固醇 (OCS) 使用有关.
结论:
- 骨质疏松症在严重喘中非常普遍,与OCS暴露,炎症,年龄,性别,喘持续时间,恶化和肺功能降低有关.
- 早期骨质疏松风险评估至关重要.
- 生物疗法在减少OCS依赖和改善长期结果方面表现有前途.
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