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女性生殖系统的器官芯片模型:目前的进展和未来的前景

Min Pan^1,2, Huike Chen¹, Kai Deng³

¹School of Medicine, Southeast University, Nanjing 210009, China.

|October 29, 2025

概括

器官芯片 (OOC) 系统为研究女性生殖系统提供先进的体外模型. 这些微生理系统正在彻底改变生殖研究和疾病建模.

科学领域:

生物医学工程生物医学工程
生殖生物学生殖生物学
微流体学微流体学

背景情况:

女性生殖系统是一个复杂的调节网络,对恒温和生殖至关重要.
传统的体外模型缺乏复杂性,无法完全复制生殖生理学.
器官在芯片 (OOC) 技术为先进的生殖研究提供了一种新的解决方案.

研究的目的:

审查女性生殖OOC系统的现状和应用.
要突出从2D/3D打印到复杂的微流体平台的进步.
讨论OOC在模拟生殖疾病和协助生殖方面的潜力.

主要方法:

微流体,3D细胞培养和生物仿真支架的整合.
开发卵巢,子宫和输卵管在芯片上的模型.
模拟荷尔蒙调节和胚胎 - 子宫内膜相互作用.

主要成果:

OOC系统能够精确模拟生殖功能和疾病机制.
这些平台有助于研究子宫内膜异位症和妇科癌症等疾病.
OOC 提供了关于生殖系统内荷尔蒙调节和器官间相互作用的见解.

结论:

OOC是模拟女性生殖生理学和病理学的变革性平台.
他们为疾病机制和个性化治疗干预提供了前所未有的洞察力.
未来的方向包括多器官集成和临床翻译,以提高理解和治疗.

关键词:

建筑方法建筑方法女性生殖系统的女性生殖系统.多器官芯片 - 多器官芯片在芯片上安装器官物理模拟生理学模拟

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