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癌症患者的维生素B12:临床见解缺乏,过量,诊断和管理
Małgorzata Osmola1, Martyna Tyszka2, Adam Jirka3
1Maria Sklodowska-Curie Medical Academy in Warsaw, 03-411 Warsaw, Poland.
Nutrients
|October 29, 2025
概括
在癌症患者中,维生素B12缺乏是常见的,可能导致贫血和恶化化疗副作用. 本综述探讨了其流行,诊断和癌症治疗中的作用.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 神经学 神经学
背景情况:
- 维生素B12 (科巴胺) 对于红细胞的形成和神经功能至关重要.
- 维生素B12缺乏与贫血和神经问题有关,在癌症患者中尤其重要.
- 它在与癌症相关的贫血和化疗诱导的周围神经病变 (CIPN) 中的作用经常被忽视.
研究的目的:
- 审查固体瘤患者中维生素B12缺乏和过量的患病率和影响.
- 讨论诊断标记,以提高瘤学的准确性.
- 评估补充剂策略以减轻CIPN,并探索B12在癌症治疗中的免疫作用.
主要方法:
- 在瘤学中对维生素B12的现有证据的文献综述.
- 分析诊断标记物,包括血清维生素B12,全转甲胺,甲基马龙酸和同类半氨酸.
- 维生素B12补充剂的评估及其对CIPN及其癌症免疫治疗的影响.
主要成果:
- 维生素B12缺乏影响了大量的癌症患者 (6-48%),特别是老年人和患有胃肠道癌的人.
- 特定的实验室标记物可以提高癌症环境中B12状态的诊断准确性.
- 维生素B12补充可能有助于管理CIPN,并在癌症治疗中具有潜在的免疫调节作用.
结论:
- 维生素B12的状况是癌症患者护理的关键因素,但尚未得到充分研究.
- 准确的诊断和适当的补充对于管理与B12相关的并发症至关重要.
- 对B12免疫作用的进一步研究可能为瘤学提供新的治疗途径.
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