循环节期确定了肥胖小鼠对长期运动的组织特异性适应
Shuo Wang1, Ziwei Zhang1, Jiapeng Huang1
1Graduate School of Sport Sciences, Waseda University, Tokorozawa 359-1192, Japan.
Nutrients
|October 29, 2025
概括
长期的运动时间影响代谢健康. 活动阶段的训练改善了脂质代谢,降低了甘油三,而休息阶段的训练在肥胖小鼠中增加了肝脏脂肪氧化.
科学领域:
- 代谢适应的发生.
- 循环生物学的日间生物.
- 运动生理学 运动生理学
背景情况:
- 运动和昼夜节律密切相关.
- 长期运动时间对肥胖的代谢适应的影响尚不清楚.
研究的目的:
- 为了研究肥胖小鼠长期运动对日间时间依赖的代谢适应.
- 探索运动时间对脂质代谢和肝氧化能力的影响.
主要方法:
- 在高脂肪饮食中的雄性C57BL/6小鼠在早期休息 (ZT3) 或早期活跃 (ZT15) 阶段接受了为期8周的跑步机训练.
- 保持了久坐的控制.
- 在禁食后分析了血甘油三和葡萄糖,肝脏和 epididymal 白脂肪组织 (EPI).
主要成果:
- 活动期运动 (ZT15) 与静止期和休息期运动的小鼠相比,显著降低了血甘油三.
- 与ZT15.15相比,休息期运动 (ZT3) 显示肝脏甘油三含量降低,脂质积累减少.
- 在EPI中,运动抑制了脂质生成 (Fasn表达),而肝脏Cpt1a表达表明氧化能力增强,特别是在ZT3训练的小鼠中.
结论:
- 长期运动会引起脂质代谢中的相位依赖性适应.
- 活动期运动促进脂质调动,降低血甘油三.
- 休息期的运动增强了肝脏的氧化能力,这表明"组织 × 时间"框架可以优化代谢障碍中的运动时间.
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