通过 Wheat Aleurone-Rich Diet 改善氧化应激:短链脂肪酸是可能的调解者吗?
Roberta Testa1, Dominic Salamone2, Angela A Rivellese1
1Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy.
Nutrients
|October 29, 2025
概括
富含小麦氨酸的饮食可以促进短链脂肪酸 (SCFA) 丁酸盐的产生,并降低患心脏代谢问题的风险人群的氧化应激. 这表明丁酸盐可能会调解小麦氨酸的抗氧化作用.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 饮食纤维研究 饮食纤维研究
背景情况:
- 众所周知,谷物中的食纤维,特别是小麦氨酸,可促进短链脂肪酸 (SCFA) 的产生.
- 酸葡萄糖与改善葡萄糖和脂质代谢,减少炎症和减少氧化应激有关.
- 关于小麦氨酸对SCFA生产和心脏代谢健康的影响的临床证据有限.
研究的目的:
- 为了研究小麦氨酸丰富的饮食与精制小麦饮食对循环SCFA度的影响.
- 检查SCFA生产和氧化应激标志物在患有心脏代谢风险较高的成年人之间的关系.
- 为了确定小麦氨酸是否增强了食后的酸盐产量.
主要方法:
- 一个随机的,为期8周的交叉试验,涉及23名腹部肥胖和代谢综合征特征的成年人.
- 参与者食用了富含小麦氨酸或精制小麦的单能饮食.
- 禁食和食后血清SCFA度使用气相色谱测量;尿液中的8-异苏通过ELISA评估了氧化应激.
主要成果:
- 与精制小麦饮食相比,小麦氨酸饮食显著增加了食后的丁酸盐反应 (p = 0.005).
- 餐后150分钟 (p = 0.027) 和180分钟 (p = 0.001) 观察到更高的丁酸盐水平.
- 180分钟后食用餐后的丁酸盐与尿液中的8-异素,氧化应激的标志物 (r = -0.618,p = 0.019) 相反相关.
结论:
- 富含小麦氨酸的饮食有效地增强了患有心脏代谢风险的个体的食后丁酸盐产量.
- 观察到的丁酸盐的增加与氧化应激的减少有关.
- 这些发现表明,丁酸盐在调解小麦氨酸的抗氧化功效方面发挥着作用,突出了其在控制心脏代谢风险方面的潜力.
更多相关视频
相关概念视频
Overview of Metabolism
37.6K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
37.6K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
631
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
631


