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希腊急性性 (AFP) 的监测:2008-2024年

Stavroula Labropoulou¹, Theano Georgakopoulou², Vahid Baniasadi³

¹National Poliovirus/Enterovirus Reference Laboratory, Hellenic Pasteur Institute, 11521 Athens, Greece.

Pathogens (Basel, Switzerland)

|October 29, 2025

概括

儿童急性软性 (AFP) 的监测对于追踪脊髓灰质炎病毒和其他病毒至关重要. 这项在希腊进行了17年的研究发现了非脊髓灰质炎肠道病毒和其他病原体,强调了持续监测的需要.

科学领域:

病毒学病毒学
公共卫生公共卫生
流行病学流行病学

背景情况:

急性软性 (AFP) 监测是全球脊髓灰质炎根除倡议的基石.
监测15岁以下儿童的AFP病例对于检测脊髓灰质炎病毒和非脊髓灰质炎肠道病毒 (NPEV) 至关重要.
希腊一直保持着无脊髓灰质炎的地位,因此需要对新出现的病毒威胁进行持续监测.

研究的目的:

分析17年来希腊AFP监测数据 (2008-2024年).
为了确定患有AFP的儿童的致病因子,特别是NPEVs.
评估AFP监测在无脊髓灰质炎国家病原体监测中的作用.

主要方法:

在2008年至2024年期间记录的256个AFP病例的回顾性分析.
使用细胞培养 (RD/L20B) 和测序进行NPEV识别的病毒隔离.
病例分布的地理分析,重点关注亚特利克亚地区.

主要成果:

18个 (7%) 便样本产生了一种病因因子:13个 (4.7%) NPEV,4个 (1.5%) 腺病毒和1个 (0.4%) 帕雷科病毒.
考克萨基病毒A,考克萨基病毒B和埃科病毒是检测到的最常见的NPEV.
人口密度最高的阿提卡地区占18个阳性标本中的10个.

结论:

在无脊髓灰质炎环境中的AFP监测对于检测超出脊髓灰质炎病毒范围的一系列病毒病原体至关重要.
这些发现强调了持续投资AFP监测对公共卫生准备的重要性.
维持希腊的无脊髓灰质炎状态和识别新出现的病毒威胁取决于持续的警.

关键词:

希腊希腊希腊希腊希腊希腊剧烈的松性麻急性麻肠道病毒病毒.脊髓灰质炎:脊髓灰质炎是一种疾病.

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