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使用压缩加热空气灭菌技术 (CHAST) 消除空气中的微生物:实验室和养老院设置
Pritha Sharma1, Supriya Mahajan2, Gene D Morse3
1Department of Medicine, Yale New Haven Health, New Haven, CT 06610, USA.
Microorganisms
|October 29, 2025
概括
压缩加热空气灭菌技术 (CHAST) 使用热量有效地使空气中的细菌,病毒和真菌失活,而不是使用化学品或过器. 这项技术在改善空气质量和在像养老院这样的脆弱环境中控制感染方面显得有前途.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 传染病控制和控制传染病
背景情况:
- 空气传播的病原体在封闭的环境中,特别是养老院中,存在重大风险.
- 养老院的居民特别容易感染感染.
- 压缩加热空气灭菌技术 (CHAST) 提供了一种新的空气灭菌方法,利用没有化学品或过器的热量.
研究的目的:
- 评估CHAST在非活化空气中的微生物方面的有效性.
- 评估CHAST在现实世界养老院环境中的可行性和性能.
- 为了确定CHAST的微生物失活值.
主要方法:
- 对CHAST原型 (300-5000 CFM; 220-247 °C) 的实验室测试,针对各种细菌和病毒替代物.
- 通过将MS2菌暴露在不同温度 (64.5-143°C) 中,评估病毒失活值.
- 关于在养老院中连续运行两个CHAST单元的可行性研究,在处理前后采取空气样本.
主要成果:
- 实验室测试表明,细菌和病毒的减少>6日志;5000CFM原型实现了>7日志减少*B. globigii*.
- 在240°C发生完整的MS2无活化,其潜在值接近170°C.
- 在养老院,CHAST操作导致排放空气中没有检测到可活生物体,并在72小时内减少了93%的真菌子.
结论:
- 切斯特有效和持续地使空气中的细菌,病毒和真菌失活.
- 该技术具有可扩展性,并显示出改善医疗机构感染控制的潜力.
- CHAST提供一种无化学品的解决方案,可提高室内空气质量,减少病原体的传播.
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