肠道微生物组与自身干细胞移植结果之间的关联:系统性审查
Ema Pitts1, Brian Grainger1, Dean McKenzie2,3
1Epworth Centre for Immunotherapies and Snowdome Laboratories, Department of Molecular Oncology and Cancer Immunology, Epworth HealthCare, Richmond, VIC 3002, Australia.
Microorganisms
|October 29, 2025
概括
自主干细胞移植 (ASCT) 破坏肠道微生物群 (GM),减少有益细菌,增加有害细菌. 了解这些转基因变化是改善ASCT后患者结果的关键.
科学领域:
- 血液学 血液学 血液学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 自主干细胞移植 (ASCT) 是多发性骨髓瘤和其他血液性恶性瘤的标准治疗方法.
- ASCT显著破坏肠道微生物群 (GM),但其对临床结果的影响仍未得到充分研究.
研究的目的:
- 审查肠道微生物组变化与ASCT后患者结果之间的关联.
- 确定当前研究中关于肠道微生物组在ASCT中的作用的缺口.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 包括11篇文章,包括观察性研究和随机对照试验.
主要成果:
- 在ASCT后,有益细菌 (例如,Bacteroidetes,Firmicutes,Faecalibacterium prausnitzii) 的持续减少.
- 病原性细菌 (例如,大肠杆菌,菌种,克莱布塞拉种) 的持续增加. 在ASCT后.
- 转基因评估技术的概述和发现的研究差距.
结论:
- 肠道微生物组的破坏是ASCT的重要后果,其特点是细菌组成的变化.
- 需要进一步的研究来充分阐明GM在ASCT结果中的作用.
- 对肠道微生物组的治疗性操纵有可能在ASCT后优化患者的治疗结果.
关键词:
自体干细胞移植自体干细胞移植我们的肠道微生物组.免疫复合 复合 免疫复合传染性并发症 传染性并发症肠道菌群是指肠道上的植物.多发性骨髓瘤是多发性骨髓瘤的一种疾病.结果就是结果.总体存活率 总体存活率没有进展的生存率.这是一个复发的复发.更多相关视频
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