冠状动脉疾病中的益生菌补充和炎症状态:系统性审查和元分析
Yuan-Yow Chiou1, Tsu-Yun Chiu2, Mei-Ju Chen3
1Department of Pediatrics, Division of Pediatric Nephrology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704302, Taiwan.
Microorganisms
|October 29, 2025
概括
益生菌补充剂可以减少冠状动脉疾病 (CAD) 患者的炎症. 这项元分析发现,益生菌显著降低了高灵敏度C反应蛋白和甲水平,这表明它在控制CAD相关炎症方面起着有益的作用.
科学领域:
- 心血管医学 心血管医学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 冠状动脉疾病 (CAD) 是全球领先的健康问题,与慢性炎症密切相关.
- 益生菌补充剂在CAD患者中调节炎症反应的潜力需要进一步研究.
研究的目的:
- 系统地审查和元分析益生菌,益生菌或协生菌对CAD患者炎症生物标志物的影响.
- 评估益生菌补充剂对CAD系统性炎症和氧化应激的影响.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在PubMed,EMBASE和Cochrane CENTRAL进行文献搜索,截至2025年3月19日.
- 包括五项随机对照试验 (256名患者),评估CAD患者的益生菌干预措施.
- 使用Cochrane协作工具进行质量评估,并计算95%置信区间 (CI) 的标准化平均差异 (SMD).
主要成果:
- 与安慰剂相比,益生菌补充剂显著降低了高灵敏度C反应蛋白 (pSMD = -0.61; 95% CI: -0.87至 -0.36) 和马隆迪 (pSMD = -0.52; 95% CI: -0.91至 -0.12) 的含量.
- 没有观察到对氧化,总抗氧化能力或谷氨水平的显著影响.
- 分析表明,它对关键的炎症和氧化应激标志物有有益影响.
结论:
- 益生菌补充剂对冠状动脉疾病患者的炎症状况产生有益影响.
- 这些发现表明,益生菌可能在减少CAD中的全身炎症和氧化应激中发挥作用.
- 进一步的研究可能会探索心血管健康的最佳益生菌菌株和剂量.
更多相关视频
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
631
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
631
Inflammatory Bowel Disease IV: Pharmacological Management
471
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
471
Coronary Artery Disease V: Interprofessional Care
210
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
210
Coronary Artery Disease IV: Preventive Measures
580
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
580
Coronary Artery Disease II: Pathophysiology
360
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
360
Coronary Artery Disease I: Introduction
869
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
869


